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Proof you CAN die of a broken heart

After Sinead O’Connor’s tragic death last year, an ex partner yesterday insisted confirmation of her dying of natural causes means she died from a ‘broken heart’.

The star, 56, was found ‘unresponsive’ by police at her flat in Herne Hill, south-east London, in July last year – 18 months after her beloved 17-year old son Shane killed himself. On Tuesday officials ruled she had died of natural causes.

Dermot Hayes, who dated singer Sinead for two years after writing an early autobiography of her, told The Irish Sun: ‘From this you can surmise that a broken heart is a real illness symptom, and a cause of death.

‘It doesn’t make Sinead’s ­passing any less painful. It was more to do with a broken heart than anything else.’

Here, Mail casino online winner examines how doctors are now looking at new ways to treat broken heart syndrome (medically known as takotsubo cardiomyopathy)…

The singer, 56, died in her flat in Herne Hill, south-east London, 18 months after her beloved 17-year old son Shane killed himself

Veterinary nurse Sarah Woodward was at work when she received a phone call to say her best friend’s father had died. 

‘I’d known him for 45 years,’ says Sarah, from Worthing, West Sussex. ‘It was like losing my own father.’

Before she’d even put the phone down, a stabbing pain started in her chest. It then radiated through her back, into her jaw and down her left arm. 

She started to struggle to breathe and turned the colour of chalk — all classic signs of a heart attack.

Sarah, 54, was, however, exceptionally fit, doing at least ten hours of exercise a week, including kickboxing. She didn’t smoke, cooked from scratch every day with husband Kevin, 58, a gas engineer, and drank alcohol only once a week.

So it never crossed her mind that she was having a heart attack. Instead, she thought it was just a panic attack or that she’d pulled a muscle while exercising.

Veterinary nurse Sarah Woodward was at work when she received a phone call to say her best friend’s father had died. ‘I’d known him for 45 years,’ says Sarah, from Worthing, West Sussex. ‘It was like losing my own father’

A colleague, however, called an ambulance and, a few hours later, tests revealed it was something else entirely. Sarah had broken heart syndrome — where there is a sudden weakening of the muscle in the heart’s left ventricle, its main pumping chamber.

The mysterious and potentially fatal condition affects around 2,500 Britons a year and often occurs after a bereavement, hence its name. 

Around 90 per cent of patients are women aged 50 or over, and around one in 20 will die in hospital as a result.

In survivors, the heart’s shape and pumping capacity usually return to normal within three months, but many suffer long-term problems including chest pain, palpitations and breathlessness.

While symptoms such as sudden intense chest pain and shortness of breath mirror those of a heart attack, takotsubo is not caused by blocked arteries — as heart attacks generally are.

Instead, says Dr David Gamble, a clinical research fellow in cardiology at the University of Aberdeen, in around 70 per cent of cases a stressful event is to blame (in other cases, the cause is unclear).

This can be emotional, such as the death of a loved one or the end of a relationship, or physical, such as an assault or car crash.

Intriguingly, the stress needn’t be negative; happy occasions can also spark the condition. A 2016 study by University Hospital Zurich in Switzerland of 485 patients whose takotsubo had an emotional trigger found that while 96 per cent had experienced sad events, in the remaining 4 per cent it followed a joyful occasion such as a birthday party, winning at a casino or even a surprise marriage proposal.

That’s because all these events — and the stress response they trigger in the body — lead to a surge in adrenaline, a hormone released to prepare the body for ‘fight or flight’ which tells the heart to beat faster to boost blood flow to the brain and muscles.

In takotsubo syndrome, however, the rush of adrenaline shuts down the bottom of the left ventricle, its main pumping chamber, says Dr Alexander Lyon, an honorary consultant cardiologist at London’s Royal Brompton Hospital. Unable to contract, the bottom of the ventricle balloons outwards.

It never crossed her mind that she was having a heart attack. Instead, she thought it was just a panic attack or that she’d pulled a muscle while exercising

This characteristic shape is visible on X-rays of the heart and is key in diagnosing the syndrome. It’s what led Japanese researchers in 1990 to name it after a ‘takotsubo’ — a traditional narrow-necked, wide-bottomed pot used to trap octopus when fishing.

One mystery for doctors seeing those affected has been understanding why this rush of adrenaline affects some people, especially women, but not others.

Now scientists may have an answer which could pave the way download casino games for android better treatments for the condition. In a study published in the journal Cardiovascular Research in June, Dr Lyon and colleagues at Imperial College London, investigated how human and rat heart cells responded to adrenaline.

They found heart cells were much more sensitive to adrenaline if they were also exposed to two molecules, microRNA-16 and microRNA-26a. In those that were, it took only about a fifth of the normal amount of adrenaline to stop them contracting.

MicroRNAs are small compounds that control protein production in cells. It’s not known from where these two emanate, but one theory is they are released by the brain in times of depression, anxiety and stress and travel in the blood to the heart.

Chronic stress may raise the levels to such an extent that some people are more likely to have a takotsubo attack when they later have a sudden shock.

Put another way, if two people experience the same rush of adrenaline after a shock, the person who has higher amounts of these microRNAs in their blood would be more likely to have a takotsubo attack, says Sian Harding, a professor of cardiac pharmacology involved in the study.

‘It may be that chronic stress is priming people to have this syndrome when they then suffer acute stress,’ she adds.

A study from Massachusetts General Hospital in March supports this theory. It found patients undergoing cancer scans who displayed heightened activity in their amygdala (the part of the brain that detects stress) were more likely to get broken heart syndrome over the next five years.

Dr Gamble says depression, anxiety and other mental health disorders are more common in those who experience takotsubo syndrome, and he is researching whether cognitive behavioural therapy (CBT) — a talking therapy that improves mental health — will aid recovery.

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Thirty patients will undergo 12 weeks of CBT and have their heart health compared with that of patients who are either prescribed a 12-week exercise programme (exercise lowers cholesterol, blood pressure and improves blood sugar regulation) or are simply treated with standard care.

Little is known about the best treatments for the syndrome, but there is some evidence ACE inhibitors, drugs prescribed to treat high blood pressure, are useful.

Genes and hormones may also play a role – genes, because the condition can run in families, and hormones because the overwhelming majority of cases are in post-menopausal women.

It is thought that male and female sex hormones may protect against the condition, leaving women more vulnerable after the menopause, when levels of oestrogen are lower. Higher levels of stress and anxiety in post-menopausal women may also help explain the link, says Dr Gamble.

One possibility in the future could be a test that measures levels of the two microRNAs identified in the recent Imperial study, to predict if a patient is at risk of experiencing a second attack of broken heart syndrome.

Similarly, drugs that block the action of the two microRNAs could provide a much-needed way of preventing recurrences.

Around one in five broken heart patients has a recurrence — and Sarah was one of them. After her first takotsubo attack she was prescribed ACE inhibitors, bonus casino no deposit online beta blockers (blood pressure drugs that block the effects of adrenaline), as well as blood thinners to reduce the risk of clots, which could cause a stroke.

On January 4, 2021, almost three years to the day since she collapsed at work, Sarah felt the same stabbing pain in her chest.

The trigger was a call from her GP in which he gave her some upsetting news about another – unrelated – health condition.

‘I remember sitting in the staff room, clutching my chest, crying and thinking I was going to die while looking at the waste-paper bin, which was overflowing. It was a feeling of utter resignation and hopelessness,’ says Sarah, who has three grown-up children.

Eight months on, she still has chest pain and breathlessness and while she still goes to the gym, she needs to nap before and intensive workouts are out of the question.

At the back of her mind is the fear she will have another attack. ‘The more I think about it,’ she says, ‘the more I worry that a third time might be the last.’

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Red Devils will pay Sancho £100k a week during Dortmund loan

Manchester United will have to pay up to £100,000-a-week towards Jadon Sancho’s wages to push through his return to Borussia Dortmund.

Talks between the two clubs are progressing over a loan deal that will see Sancho end his United misery by rejoining Dortmund on loan until the end of the season.

The final sticking point is understood to be Sancho’s £290,000-a-week salary which is well above Dortmund’s pay ceiling. The Bundesliga club are insisting that United contribute a third of the cost, Confidential understands.

Old Trafford sources won’t comment on the specifics of the deal but confirm that a large majority of Sancho’s wages will be covered by Dortmund, and additional payments are built into the deal based on the 23-year-old’s appearances and the Germans qualifying for the Champions League. It’s understood there will be no obligation to buy the player at the end of the season.

United will certainly view paying a portion of Sancho’s wages and putting him in the shop window as preferable to footing the whole bill while he trains and eats on his own at Carrington, which has been the case since he made the last of his three appearances this season in late August following a public fall-out with manager Erik ten Hag.

Manchester United will have to pay up to £100,000-a-week towards Jadon Sancho’s wages at Borussia Dortmund

Talks between the two clubs are progressing over a loan deal that will see Sancho end his United misery by rejoining Dortmund on loan until the end of the season

Your browser does not support iframes.

The winger’s refusal to apologise looks likely to spell the end of a hugely disappointing spell at Old Trafford, which began with a £73million move from Dortmund in the summer of 2021.

Although United will be paying Sancho around £2.5m to play elsewhere, the club will save up to £5m on his salary between now and the end of June as they continue to drive down the wage bill to help meet Financial Fair Play requirements.

Eintracht Frankfurt are also covering the majority of Donny van de Beek’s wages following his move to Germany and have paid United a loan fee.

United will get Anthony Martial’s £250,000-a-week salary off the books by the summer after deciding against giving the striker or his French compatriot Raphael Varane a 12-month contract extension. The club are still open to keeping Varane on a new deal if he will agree to take a cut on his £340,000-a-week wages.

FFP will also limit what United can spend this month, and it’s believed there are currently no negotiations taking place over potential new signings.

The winger’s refusal to apologise to Erik ten Hag (pictured) looks likely to end his disappointing spell at Old Trafford

 

Fans hit by Wigan shut-out

Dozens of United fans missed the opening half an hour of the FA Cup tie at Wigan on Monday night because of a fault with the turnstiles.

The League One club opted for a fully-automated entry system, which caused chaos for some of the 7,500 visiting supporters.

Fans whose tickets failed to scan were refused access and instead sent to the ticket office, where they were met with long queues and a lack of organisation.

Stewards at the turnstiles said they had been told not to intervene and could not let supporters through, even if they had a valid ticket.

One told Confidential there is usually someone on hand to help but Wigan decided to change the system, raising questions over why they chose to do so for what is likely to be the best-attended match at the DW Stadium this season.

Manchester United beat Wigan but dozens of fans missed the opening 30 minutes of the game

 

Skinner row mars Malta trip

A warm-weather training camp in Malta didn’t quite provide United women’s team boss Marc Skinner with the relaxing environment he may have been hoping for.

A 1-0 defeat by Liverpool before Christmas saw fans call for Skinner’s head, and a group of supporters who travelled to the Mediterranean did the same when they watched the club’s friendly with PSV Eindhoven on Friday.

But there was controversy when some fans claimed on X, formerly known as Twitter, that a member of the club’s security team had asked them to stop singing ‘Skinner out’.

A letter of complaint was sent to United’s official supporters club for the women’s team and shared on social media. Fans claimed the member of staff said their chants were ‘upsetting players’.

It is understood the club are happy with the way the member of staff approached the situation and that they acted appropriately and proportionately. It is also understood the club are happy with the job Skinner has done since taking over from Casey Stoney in July 2021.

Visit Malta is United’s official destination partner and one of their largest overseas supporters’ clubs. Players took part in an open training session on Sunday where some of the local fans were invited to meet the squad.

A warm-weather training camp in Malta didn’t quite provide United women’s team boss Marc Skinner with the relaxing environment he may have been hoping for

 

PSV lead Pellistri race

More departures are expected before the end of the January transfer window, but Erik ten Hag wants to be sure of the players returning from injury before sanctioning any loan moves besides Jadon Sancho and Donny van de Beek.

United had a young bench for Monday’s FA Cup third round win at Wigan, which saw Facundo Pellistri, Hannibal Mejbri, Omari Forson and Willy Kambwala make late substitute appearances.

Pellistri is being lined up for a loan move to PSV Eindhoven despite rival interest from Flamengo and Villarreal, as reported in Mail Sport at the weekend. Mejbri is a target for Sevilla and Everton after dropping out of Tunisia’s squad for the Africa Cup of Nations to decide on his next move, and Dan Gore could also go out on loan to an EFL club.

Amad Diallo is likely to remain part of Ten Hag’s first-team plans after impressing the manager since his return from a knee injury.

Facundo Pellistri (left) is being lined up casinos online for real money a loan move to Dutch side PSV Eindhoven

 

Fernandez fear for Spaniards

There are growing concerns at Granada that United defender Alvaro Fernandez will be recalled from his loan spell at the Spanish club.

While Granada remained tight-lipped when approached by Confidential, sources in Spain have indicated there are worries that the left-back could be brought back to Old Trafford this month.

It is understood United are still weighing up their options as to how to manage the 20-year-old, who is out of contract in the summer.

There are fears at Granada that Man United could look to recall Alvaro Fernandez

 

Onana set for Cameroon bench

The news that United were in discussions to keep Andre Onana for Sunday’s clash with Tottenham before he travelled to the Africa Cup of Nations, revealed in last week’s Confidential, raised the prospect of the Cameroon goalkeeper playing twice in the space of 24 hours.

However, it’s unlikely Onana will start against Guinea on Monday, with the United keeper set to be on the bench for the Group C opener in Yamoussoukro as back-up for his distant cousin Fabrice Ondoa, of French club Nimes.

Cameroon play a final warm-up casino game win against Zambia on Tuesday in Jeddah where the temperature in Saudi Arabia is touching 30 degrees – a far cry from the freezing temperatures in Wigan where Onana played for United on Monday night.

Andre Onana is likely to be on the bench for Cameroon’s Africa Cup of Nations opener

 

Martinez’s comeback spur

Ten Hag said after the win over Wigan that Christian Eriksen, Luke Shaw and Harry Maguire all have a chance of returning to action against Spurs. Confidential understands that Lisandro Martinez could yet make a surprise comeback as well.

The Argentine has not played since the Champions League defeat to Bayern Munich at the Allianz Arena in mid-September after needing a second operation on the broken metatarsal in his right foot that cut short his first season at United.

Martinez and Casemiro rejoined full training last week but Ten Hag said before the trip to Wigan that it might be weeks before the pair are fit to play again. However, Martinez is said to be chomping at the bit and is targeting the Spurs clash at Old Trafford on Sunday as a possible date for his return.

Tyrell Malacia is another long-term absentee who is close to playing again following knee surgery, but Mason Mount may be the last one back after taking longer than expected to recover from a calf injury.

Lisandro Martinez could make a shock return in Man United’s clash against Tottenham

The return of Martinez (second left) will give Ten Hag’s side a boost for the second-half of the campaign

 

The masked winger

United caused fierce debate on social media by going viral with a guessing game for fans.

One very cold player emerged for casino slot game apps training with a snood over his head and fans were tasked with guessing who it is. 

The simple post has had more than 2.3million views in what is comfortably United’s biggest social media win of the year so far. So, can you guess who it is?

Manchester United left fans guessing who this player is who had their face covered in a picture

 

SAS challenge for Utd

United’s stars have been on the ropes for much of this season but now they have been offered the chance to be put through the ringer in a different sort of way.

SAS ‘Who Dares Wins’ host Ant Middleton has offered to try and cure the ills of Erik ten Hag’s under-performing side with a special boot-camp for extreme team building and bonding.

Middleton posted: ‘@ManUtd Let’s do this! For extreme team building and bonding please contact the Ant Middleton world of extremes!’

SAS ‘Who Dares Wins’ host Ant Middleton has offered to try and cure the ills of Erik ten Hag’s under-performing side with a special boot-camp for extreme team building and bonding

@ManUtd Let’s do this! For extreme team building and bonding please contact the Ant Middleton world of extremes! For more information email enquires@antmiddleton.com pic.twitter.com/rBwJyNRMnu

— Ant Middleton (@antmiddleton) January 7, 2024

 

Gabe’s boxing clever

United youngster Gabriele Bancheri is one to watch in the coming years. The 17-year-old Wales starlet, who signed from Cardiff City for a six-figure fee last year, is winning rave reviews behind the scenes and he is not resting on his laurels as he bids to make the tricky step all the way through to the first team.

Instead of cruising through into the New Year, the Welsh youngster teamed up to train with two-time super-featherweight boxing world champion Joe Cordina.

The pair have become good friends and were putting each other through gruelling sand dune endurance drills at Merthyr Mawr in South Wales.

Bancheri took his rigorous fitness regime into the Mercedes Benz Junior Cup earlier this week and scored as United’s U19s finished fifth.

 

Buchan back on course 

Legendary United captain Martin Buchan is due to have a cataract operation on Saturday that he hopes will allow him to play golf into his 76th year.

Buchan, who will always be remembered for leading United in the 1977 FA Cup Final which stopped Liverpool from winning the Treble, turns 75 in March but feared eye problems would stop him from continuing to play his beloved golf.

However, cataract surgery on his left eye has already taken place and now he’s about to have the right one done, joking: ‘If the op had been set for Friday the 13th I would have said real online casino no deposit, but Saturday the 13th is okay!’

Buchan, who still lives in the north-west, was visiting family in his native Aberdeen when he heard of the sad news that his football idol and fellow centre-half Franz Beckenbauer had passed away.

‘It was one of the highlights of my career to be on the same pitch as him when Scotland played West Germany in a friendly before the 1974 World Cup,’ recalls Buchan.

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Rallying-Ogier chasing record 10th Monte Carlo win as new season…

Jan 24 (Reuters) – Eight-times world rally champion Sebastien Ogier is still hungry for success, even as a Toyota part-timer, as he starts a new season chasing a record-extending 10th Monte Carlo Rally win this weekend.

The oldest and most evocative round of the championship is based in the south-eastern town of Gap, the 40-year-old French driver’s birthplace, and he knows the treacherous mountain roads as well as anyone.

“Numbers are never my main motivation, but if I could get a 10th win on this event it would be something very special,” last year’s winner said in the build-up to an asphalt rally notorious for ice and snow.

“I think it´s the rally that you need to respect more than any other as the conditions can be so challenging, which means that nothing is guaranteed.”

Team mate and reigning champion Kalle Rovanpera is taking time out this season, driving selected events, with Welshman Elfyn Evans Toyota’s main title contender after finishing overall runner-up three times in the past four years.

Evans has yet to win in Monte Carlo, finishing second in 2021.

Estonia’s Ott Tanak, returning to Hyundai after a year away at M-Sport Ford, led the way in Wednesday’s short and dry shakedown ahead of Evans and Hyundai’s Thierry Neuville with Ogier fourth.

“It´s always a difficult challenge,” commented Tanak. “Even if I’ve been here before, it’s still a little bit unknown.”

The big change in the championship for this season is a new scoring system aimed at providing more excitement on the final day.

Points will now be allocated at the end of Saturday’s action on a scale of 18-15-13-10-8-6-4-3-2-1 and providing the crews complete the rally on Sunday, with the final day providing more points on a 7-6-5-4-3-2-1 basis.

The final Power Stage offers up to a further five bonus points.

The rally proper starts with two evening stages on Thursday, online slots app with three stages run twice each on Friday and again on Saturday before the finish on Sunday and official prize-giving in Monaco’s Casino Square. (Reporting by Alan Baldwin in London, editing by Pritha Sarkar)

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